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Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells.
Hu W, Zhang L, Li MX, Shen J, Liu XD, Xiao ZG, Wu DL, Ho IHT, Wu JCY, Cheung CKY, Zhang YC, Lau AHY, Ashktorab H, Smoot DT, Fang EF, Chan MTV, Gin T, Gong W, Wu WKK, Cho CH. Hu W, et al. Autophagy. 2019 Apr;15(4):707-725. doi: 10.1080/15548627.2018.1557835. Epub 2019 Jan 6. Autophagy. 2019. PMID: 30612517 Free PMC article.
Once infected, it is difficult for the host to clear this organism using the innate immune system. Increased antibiotic resistance further makes it challenging for effective eradication. ...Vitamin D3 treatment caused a restored lysosomal degradation function by act …
Once infected, it is difficult for the host to clear this organism using the innate immune system. Increased antibiotic resist …
Multifunctional molecule ERp57: From cancer to neurodegenerative diseases.
Hettinghouse A, Liu R, Liu CJ. Hettinghouse A, et al. Pharmacol Ther. 2018 Jan;181:34-48. doi: 10.1016/j.pharmthera.2017.07.011. Epub 2017 Jul 16. Pharmacol Ther. 2018. PMID: 28723413 Free PMC article. Review.
Here, we summarize available knowledge of ERp57's functions in subcellular compartments and the roles of dysregulated ERp57 in various diseases toward an emphasis on the potential utility of therapeutic development of ERp57....
Here, we summarize available knowledge of ERp57's functions in subcellular compartments and the roles of dysregulated ERp57 in various di …
Single or Combined Dietary Supply of Psidium guajava and Phyllanthus amarus Extracts Differentially Modulate Immune Responses and Liver Proteome in Striped Catfish (Pangasianodon hyphophthalmus).
Nhu TQ, Bich Hang BT, Cornet V, Oger M, Bach LT, Anh Dao NL, Thanh Huong DT, Quetin-Leclercq J, Scippo ML, Phuong NT, Kestemont P. Nhu TQ, et al. Front Immunol. 2020 May 5;11:797. doi: 10.3389/fimmu.2020.00797. eCollection 2020. Front Immunol. 2020. PMID: 32431710 Free PMC article.
Guava Psidium guajava L (Pg) and bhumi amla Phyllanthus amarus Schum. et Thonn (Pa) are well-known plants in traditional medicine. However, the capacity of these plants for improving the immune system of aquatic species has received less attention so far. ...Taken t …
Guava Psidium guajava L (Pg) and bhumi amla Phyllanthus amarus Schum. et Thonn (Pa) are well-known plants in traditional medicine. However, …
Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics.
Chamberlain N, Korwin-Mihavics BR, Nakada EM, Bruno SR, Heppner DE, Chapman DG, Hoffman SM, van der Vliet A, Suratt BT, Dienz O, Alcorn JF, Anathy V. Chamberlain N, et al. Redox Biol. 2019 Apr;22:101129. doi: 10.1016/j.redox.2019.101129. Epub 2019 Jan 29. Redox Biol. 2019. PMID: 30735910 Free PMC article.
However, it is unknown whether these host-viral protein interactions occur during active infection and whether such interactions represent a putative target for the treatment of influenza infection. Here we show that PDIA3 is specifically upregulated in IAV-infected mouse …
However, it is unknown whether these host-viral protein interactions occur during active infection and whether such interactions represent a …
Proteomics analysis of lysine crotonylation and 2-hydroxyisobutyrylation reveals significant features of systemic lupus erythematosus.
Xie T, Dong J, Zhou X, Tang D, Li D, Chen J, Chen Y, Xu H, Xue W, Liu D, Hong X, Tang F, Yin L, Dai Y. Xie T, et al. Clin Rheumatol. 2022 Dec;41(12):3851-3858. doi: 10.1007/s10067-022-06254-4. Epub 2022 Aug 8. Clin Rheumatol. 2022. PMID: 35941338 Free PMC article.
KEGG pathways were enriched in antigen processing and presentation pathway and leukocyte transendothelial migration pathway. Six DMPs (CLTC, HSPA1B, HSPA8, HSP90AB1, HSPD1, and PDIA3) were identified in antigen processing and presentation pathway, of which HSPA8 was the co …
KEGG pathways were enriched in antigen processing and presentation pathway and leukocyte transendothelial migration pathway. Six DMPs (CLTC, …
Differentially expressed proteins in the intestine of Cynoglossus semilaevis Günther following a Shewanella algae challenge.
Han Z, Sun J, Wang A, Lv A, Hu X, Chen L, Guo Y. Han Z, et al. Fish Shellfish Immunol. 2020 Sep;104:111-122. doi: 10.1016/j.fsi.2020.06.013. Epub 2020 Jun 7. Fish Shellfish Immunol. 2020. PMID: 32525078
Fish intestine is an important constituent of the mucosal immune system. The gut and gut-associated lymphoid tissue construct a local immune environment. ...Among them, 29 DEPs were related to stress, immune, and metabolism processes. In the network, s …
Fish intestine is an important constituent of the mucosal immune system. The gut and gut-associated lymphoid tissue construct …
Structure of the human MHC-I peptide-loading complex.
Blees A, Januliene D, Hofmann T, Koller N, Schmidt C, Trowitzsch S, Moeller A, Tampé R. Blees A, et al. Nature. 2017 Nov 23;551(7681):525-528. doi: 10.1038/nature24627. Epub 2017 Nov 6. Nature. 2017. PMID: 29107940
The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establishing a hierarchical immune response. The PLC coordinates peptide translocation into the endoplasmic reticulum with loading and editing …
The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establish …
The role of protein disulphide-isomerase A3 as autoantigen in the pathogenesis of autoimmune thyroiditis and related brain damage in adult mice.
Yang W, Xiang Y, Zhang H, Shan Z, Li J, Teng W. Yang W, et al. Clin Immunol. 2020 Mar;212:108350. doi: 10.1016/j.clim.2020.108350. Epub 2020 Jan 23. Clin Immunol. 2020. PMID: 31982645
PDIA3-expressing cells had IgG deposition, and IgG colocalized with C3 in the thyroid and brain tissues of PDIA3-immunized mice, resulting in membrane attack complex formation. Our results suggest that PDIA3 protein may be a common autoantigen shared by the t …
PDIA3-expressing cells had IgG deposition, and IgG colocalized with C3 in the thyroid and brain tissues of PDIA3-immunized mic …
Identification of candidate synovial membrane biomarkers after Achyranthes aspera treatment for rheumatoid arthritis.
Zheng W, Lu X, Fu Z, Zhang L, Li X, Xu X, Ren Y, Lu Y, Fu H, Tian J. Zheng W, et al. Biochim Biophys Acta. 2016 Mar;1864(3):308-316. doi: 10.1016/j.bbapap.2015.12.010. Epub 2015 Dec 24. Biochim Biophys Acta. 2016. PMID: 26724776
Finally, autoantigens such as fibrinogen and collagen could act as inducers of RA due to their aggravation of inflammation. Given this, it is possible that the vimentin and PDIA3 could be the candidate biomarkers specific to Achyranthes saponin therapy for rheumatoid arthr …
Finally, autoantigens such as fibrinogen and collagen could act as inducers of RA due to their aggravation of inflammation. Given this, it i …
Exonic variants of genes related to the vitamin D signaling pathway in the families of familial multiple sclerosis using whole-exome next generation sequencing.
Pytel V, Matías-Guiu JA, Torre-Fuentes L, Montero-Escribano P, Maietta P, Botet J, Álvarez S, Gómez-Pinedo U, Matías-Guiu J. Pytel V, et al. Brain Behav. 2019 Apr;9(4):e01272. doi: 10.1002/brb3.1272. Epub 2019 Mar 21. Brain Behav. 2019. PMID: 30900415 Free PMC article.
INTRODUCTION: Vitamin D (VD) deficiency has been associated with multiple sclerosis (MS) and other autoimmune diseases (AIDs). However, the effect of the genetics of VD on the risk of MS is subject to debate. ...We performed whole-exome next generation sequencing on all in …
INTRODUCTION: Vitamin D (VD) deficiency has been associated with multiple sclerosis (MS) and other autoimmune diseases (AIDs). Howeve …
22 results